Nature Communications (Sep 2019)

MHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates

  • Romina Aron Badin,
  • Aurore Bugi,
  • Susannah Williams,
  • Marta Vadori,
  • Marie Michael,
  • Caroline Jan,
  • Alberto Nassi,
  • Sophie Lecourtois,
  • Antoine Blancher,
  • Emanuele Cozzi,
  • Philippe Hantraye,
  • Anselme L. Perrier

DOI
https://doi.org/10.1038/s41467-019-12324-0
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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Matching iPSC donors’ and patients’ HLA haplotypes has been proposed as a way to generate cell therapy products with enhanced immunological compatibility. Here the authors show that MHC matching alone is insufficient to grant long-term survival of neuronal grafts in the lesioned brain of non-human primates.