Nature Communications (Nov 2022)
Structural basis of organic cation transporter-3 inhibition
- Basavraj Khanppnavar,
- Julian Maier,
- Freja Herborg,
- Ralph Gradisch,
- Erika Lazzarin,
- Dino Luethi,
- Jae-Won Yang,
- Chao Qi,
- Marion Holy,
- Kathrin Jäntsch,
- Oliver Kudlacek,
- Klaus Schicker,
- Thomas Werge,
- Ulrik Gether,
- Thomas Stockner,
- Volodymyr M. Korkhov,
- Harald H. Sitte
Affiliations
- Basavraj Khanppnavar
- Laboratory of Biomolecular Research, Paul Scherrer Institute
- Julian Maier
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- Freja Herborg
- Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen
- Ralph Gradisch
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- Erika Lazzarin
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- Dino Luethi
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- Jae-Won Yang
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- Chao Qi
- Laboratory of Biomolecular Research, Paul Scherrer Institute
- Marion Holy
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- Kathrin Jäntsch
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- Oliver Kudlacek
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- Klaus Schicker
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- Thomas Werge
- Institute of Biological Psychiatry, Mental Health Services Copenhagen
- Ulrik Gether
- Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen
- Thomas Stockner
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- Volodymyr M. Korkhov
- Laboratory of Biomolecular Research, Paul Scherrer Institute
- Harald H. Sitte
- Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna
- DOI
- https://doi.org/10.1038/s41467-022-34284-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
The current work reports the structure of the human organic cation transporter 3 (OCT3 / SLC22A3) and provides the structural basis of its inhibition by two specific inhibitors, decynium-22 and corticosterone.
