Targeting ATR/CHK1 pathway in acute myeloid leukemia to overcome chemoresistance

Abstract

Resistance of acute myeloid leukemia to current therapies leads to frequent relapses. Identification of molecular mechanisms involved in chemoresistance constitutes a key challenge to define new therapeutic concepts. Here, we show that the ATR/CHK1 pathway, essential in maintaining genomic stability, is involved in resistance and proliferation characteristics of leukemic cells.

Keywords

• acute myeloid leukemia
• atr and chk1 kinases
• chemoresistance
• dna replicative stress