Antibiotics (Apr 2023)

Recent Advances in Pharmaceutical Approaches of Antimicrobial Agents for Selective Delivery in Various Administration Routes

  • Ardiyah Nurul Fitri Marzaman,
  • Tri Puspita Roska,
  • Sartini Sartini,
  • Rifka Nurul Utami,
  • Sulistiawati Sulistiawati,
  • Cindy Kristina Enggi,
  • Marianti A. Manggau,
  • Latifah Rahman,
  • Venkatram Prasad Shastri,
  • Andi Dian Permana

DOI
https://doi.org/10.3390/antibiotics12050822
Journal volume & issue
Vol. 12, no. 5
p. 822

Abstract

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Globally, the increase of pathogenic bacteria with antibiotic-resistant characteristics has become a critical challenge in medical treatment. The misuse of conventional antibiotics to treat an infectious disease often results in increased resistance and a scarcity of effective antimicrobials to be used in the future against the organisms. Here, we discuss the rise of antimicrobial resistance (AMR) and the need to combat it through the discovery of new synthetic or naturally occurring antibacterial compounds, as well as insights into the application of various drug delivery approaches delivered via various routes compared to conventional delivery systems. AMR-related infectious diseases are also discussed, as is the efficiency of various delivery systems. Future considerations in developing highly effective antimicrobial delivery devices to address antibiotic resistance are also presented here, especially on the smart delivery system of antibiotics.

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