Comprehensive two-dimensional liquid chromatography in food analysis. Is any sample preparation necessary?

Laura Martín-Pozo; Katia Arena; Francesco Cacciola; Paola Dugo; Luigi Mondello

Green Analytical Chemistry (Dec 2022)

Comprehensive two-dimensional liquid chromatography in food analysis. Is any sample preparation necessary?

Laura Martín-Pozo,
Katia Arena,
Francesco Cacciola,
Paola Dugo,
Luigi Mondello

Affiliations

Laura Martín-Pozo: Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Campus Fuentenueva s/n, 18071 Granada, Spain; Department of Chemical Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy
Katia Arena: Department of Chemical Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy
Francesco Cacciola: Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, 98125 Messina, Italy; Corresponding author.
Paola Dugo: Department of Chemical Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy; Chromaleont s.r.l., c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy
Luigi Mondello: Department of Chemical Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy; Chromaleont s.r.l., c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy; Department of Sciences and Technologies for Human and Environment, University Campus Bio-Medico of Rome, 00128 Rome, Italy

Journal volume & issue: Vol. 3
p. 100025

Abstract

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Comprehensive two-dimensional liquid chromatography (LC × LC) is a valuable and powerful tool for the analysis of complex real-world samples. The present review paper highlights the advantages, arising from the coupling of two different liquid chromatography separations in the sector of food analysis. The first part is devoted to both theoretical and practical considerations about method optimization; on the other hand, selected applications pertaining to polyphenol, triacylglycerol and carotenoid analysis where no sample preparation is needed (green approach) are reported and discussed. In this context, the LC × LC methodology become a promising greener and ecofriendly alternative that may reduce analysis time and solvent consumption.

Published in Green Analytical Chemistry

ISSN: 2772-5774 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry: Analytical chemistry
Website: https://www.sciencedirect.com/journal/green-analytical-chemistry

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