Nature Communications (May 2020)

TALPID3 and ANKRD26 selectively orchestrate FBF1 localization and cilia gating

  • Hao Yan,
  • Chuan Chen,
  • Huicheng Chen,
  • Hui Hong,
  • Yan Huang,
  • Kun Ling,
  • Jinghua Hu,
  • Qing Wei

DOI
https://doi.org/10.1038/s41467-020-16042-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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Most cells possess sensory cilia, which need to be gated properly. Here the authors show that the C. elegans proteins TALP-3 and ANKR-26 coordinate cilia gating in the context of transition fibers and that this mechanism is conserved in mammalian cells and likely implicated in certain ciliopathies.