Nature Communications (Apr 2020)

TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits

  • Juan Ji An,
  • Clint E. Kinney,
  • Ji-Wei Tan,
  • Guey-Ying Liao,
  • Eric J. Kremer,
  • Baoji Xu

DOI
https://doi.org/10.1038/s41467-020-15537-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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The TrkB receptor is known to regulate obesity via appetite control, but the underlying neural circuits are not known. Here, the authors show that selective modulation of TrkB+ neurons in the paraventricular hypothalamus regulates food intake via circuits to ventromedial hypothalamus and lateral parabrachial nucleus.