A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids

Junlin Wang; Yanan Zhang; Huanhuan Liu; Yong Shang; Linjun Zhou; Penglin Wei; Wen-Bing Yin; Zixin Deng; Xudong Qu; Qianghui Zhou

doi:10.1038/s41467-019-11344-0

Nature Communications (Jul 2019)

A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids

Junlin Wang,
Yanan Zhang,
Huanhuan Liu,
Yong Shang,
Linjun Zhou,
Penglin Wei,
Wen-Bing Yin,
Zixin Deng,
Xudong Qu,
Qianghui Zhou

Affiliations

Junlin Wang: Sauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), Institute for Advanced Studies, College of Chemistry and Molecular Sciences, Wuhan University
Yanan Zhang: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University
Huanhuan Liu: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University
Yong Shang: Sauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), Institute for Advanced Studies, College of Chemistry and Molecular Sciences, Wuhan University
Linjun Zhou: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University
Penglin Wei: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences
Wen-Bing Yin: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences
Zixin Deng: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University
Xudong Qu: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University
Qianghui Zhou: Sauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), Institute for Advanced Studies, College of Chemistry and Molecular Sciences, Wuhan University

DOI: https://doi.org/10.1038/s41467-019-11344-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

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C19 hydroxylation is a unique feature of some bioactive steroids. Here, the authors developed a direct C19 hydroxylation approach to scalably access 19-OH-cortexolone in the host T. cucumeris and then converted the product into various pharmaceutically useful products via chemical synthesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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