Iraqi Journal of Pharmaceutical Sciences (Jun 2020)

Co-Amorphous System: A promising Strategy for Delivering Poorly Water - Soluble Drugs

  • Eman S. Aldahhan,
  • Ameera A. Radhi

DOI
https://doi.org/10.31351/vol29iss1pp1-11
Journal volume & issue
Vol. 29, no. 1
pp. 1 – 11

Abstract

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Amorphization of drug has been considered as an attractive approach in improving drug solubility and bioavailability. Unlike their crystalline counterparts, amorphous materials lack the long-range order of molecular packing and present the highest energy state of a solid material. Co-amorphous systems (CAM) are an innovative formulation technique by where the amorphous drugs are stabilized via powerful intermolecular interactions by means of a low molecular co-former. This review highlights the different approaches in the preparation of co-amorphous drug delivery system, the proper selection of the co-formers. In addition, the recent advances in characterization, Industrial scale and formulation will be discussed.

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