Nature Communications (Oct 2020)
Circulating tumour DNA from the cerebrospinal fluid allows the characterisation and monitoring of medulloblastoma
- Laura Escudero,
- Anna Llort,
- Alexandra Arias,
- Ander Diaz-Navarro,
- Francisco Martínez-Ricarte,
- Carlota Rubio-Perez,
- Regina Mayor,
- Ginevra Caratù,
- Elena Martínez-Sáez,
- Élida Vázquez-Méndez,
- Iván Lesende-Rodríguez,
- Raquel Hladun,
- Luis Gros,
- Santiago Ramón y Cajal,
- Maria A. Poca,
- Xose S. Puente,
- Juan Sahuquillo,
- Soledad Gallego,
- Joan Seoane
Affiliations
- Laura Escudero
- Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital
- Anna Llort
- Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron University Hospital
- Alexandra Arias
- Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital
- Ander Diaz-Navarro
- Dpto. de Bioquímica y Biología Molecular, IUOPA-Universidad de Oviedo
- Francisco Martínez-Ricarte
- Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron University Hospital
- Carlota Rubio-Perez
- Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital
- Regina Mayor
- Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital
- Ginevra Caratù
- Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital
- Elena Martínez-Sáez
- Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron University Hospital
- Élida Vázquez-Méndez
- Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron University Hospital
- Iván Lesende-Rodríguez
- Universidade de A Coruña (UDC)
- Raquel Hladun
- Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron University Hospital
- Luis Gros
- Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron University Hospital
- Santiago Ramón y Cajal
- Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron University Hospital
- Maria A. Poca
- Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron University Hospital
- Xose S. Puente
- Dpto. de Bioquímica y Biología Molecular, IUOPA-Universidad de Oviedo
- Juan Sahuquillo
- Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron University Hospital
- Soledad Gallego
- Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron University Hospital
- Joan Seoane
- Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron University Hospital
- DOI
- https://doi.org/10.1038/s41467-020-19175-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
Non-invasive and precise methods are critical for monitoring paediatric brain cancers. Here the authors show that the molecular alterations and heterogeneity of paediatric medulloblastomas can be reliably detected in circulating tumour DNA from the cerebrospinal fluid – a routinely collected sample.
