Virology Journal (May 2020)
Host shutoff activity of VHS and SOX-like proteins: role in viral survival and immune evasion
- Tianqiong He,
- Mingshu Wang,
- Anchun Cheng,
- Qiao Yang,
- Ying Wu,
- Renyong Jia,
- Mafeng Liu,
- Dekang Zhu,
- Shun Chen,
- Shaqiu Zhang,
- Xin-Xin Zhao,
- Juan Huang,
- Di Sun,
- Sai Mao,
- Xuming Ou,
- Yin Wang,
- Zhiwen Xu,
- Zhengli Chen,
- Lin Zhu,
- Qihui Luo,
- Yunya Liu,
- Yanling Yu,
- Ling Zhang,
- Bin Tian,
- Leichang Pan,
- Mujeeb Ur Rehman,
- Xiaoyue Chen
Affiliations
- Tianqiong He
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Mingshu Wang
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Anchun Cheng
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Qiao Yang
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Ying Wu
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Renyong Jia
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Mafeng Liu
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Dekang Zhu
- Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University
- Shun Chen
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Shaqiu Zhang
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Xin-Xin Zhao
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Juan Huang
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Di Sun
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Sai Mao
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Xuming Ou
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Yin Wang
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Zhiwen Xu
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Zhengli Chen
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Lin Zhu
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Qihui Luo
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Yunya Liu
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Yanling Yu
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Ling Zhang
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Bin Tian
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Leichang Pan
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Mujeeb Ur Rehman
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- Xiaoyue Chen
- Institute of Preventive Veterinary Medicine, Sichuan Agricultural University
- DOI
- https://doi.org/10.1186/s12985-020-01336-8
- Journal volume & issue
-
Vol. 17,
no. 1
pp. 1 – 11
Abstract
Abstract Background Host shutoff refers to the widespread downregulation of host gene expression and has emerged as a key process that facilitates the reallocation of cellular resources for viral replication and evasion of host antiviral immune responses. Main body The Herpesviridae family uses a number of proteins that are responsible for host shutoff by directly targeting messenger RNA (mRNA), including virion host shutoff (VHS) protein and the immediate-early regulatory protein ICP27 of herpes simplex virus types 1 (HSV-1) and the SOX (shutoff and exonuclease) protein and its homologs in Gammaherpesvirinae subfamilies, although these proteins are not homologous. In this review, we highlight evidence that host shutoff is promoted by the VHS, ICP27 and SOX-like proteins and that they also contribute to immune evasion. Conclusions Further studies regarding the host shutoff proteins will not only contribute to provide new insights into the viral replication, expression and host immune evasion process, but also provide new molecular targets for the development of antiviral drugs and therapies.
Keywords
