Cross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes

Abstract

Synaptic vesicles store neurotransmitters and fuse with the pre-synaptic membrane when an action potential arrives at the nerve terminal. Here authors apply cross-linking mass spectrometry to study interactions of synaptic vesicle proteins and describe a protein network of vesicle sub-populations and functional assemblies.