Nature Communications (Jul 2016)
Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
- Jonathan S. Mitchell,
- Ni Li,
- Niels Weinhold,
- Asta Försti,
- Mina Ali,
- Mark van Duin,
- Gudmar Thorleifsson,
- David C. Johnson,
- Bowang Chen,
- Britt-Marie Halvarsson,
- Daniel F. Gudbjartsson,
- Rowan Kuiper,
- Owen W. Stephens,
- Uta Bertsch,
- Peter Broderick,
- Chiara Campo,
- Hermann Einsele,
- Walter A. Gregory,
- Urban Gullberg,
- Marc Henrion,
- Jens Hillengass,
- Per Hoffmann,
- Graham H. Jackson,
- Ellinor Johnsson,
- Magnus Jöud,
- Sigurður Y. Kristinsson,
- Stig Lenhoff,
- Oleg Lenive,
- Ulf-Henrik Mellqvist,
- Gabriele Migliorini,
- Hareth Nahi,
- Sven Nelander,
- Jolanta Nickel,
- Markus M. Nöthen,
- Thorunn Rafnar,
- Fiona M. Ross,
- Miguel Inacio da Silva Filho,
- Bhairavi Swaminathan,
- Hauke Thomsen,
- Ingemar Turesson,
- Annette Vangsted,
- Ulla Vogel,
- Anders Waage,
- Brian A. Walker,
- Anna-Karin Wihlborg,
- Annemiek Broyl,
- Faith E. Davies,
- Unnur Thorsteinsdottir,
- Christian Langer,
- Markus Hansson,
- Martin Kaiser,
- Pieter Sonneveld,
- Kari Stefansson,
- Gareth J. Morgan,
- Hartmut Goldschmidt,
- Kari Hemminki,
- Björn Nilsson,
- Richard S. Houlston
Affiliations
- Jonathan S. Mitchell
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Ni Li
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Niels Weinhold
- Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences
- Asta Försti
- German Cancer Research Center
- Mina Ali
- Department of Laboratory Medicine, Hematology and Transfusion Medicine
- Mark van Duin
- Department of Hematology, Erasmus MC Cancer Institute
- Gudmar Thorleifsson
- deCODE Genetics
- David C. Johnson
- Division of Molecular Pathology, The Institute of Cancer Research
- Bowang Chen
- German Cancer Research Center
- Britt-Marie Halvarsson
- Department of Laboratory Medicine, Hematology and Transfusion Medicine
- Daniel F. Gudbjartsson
- deCODE Genetics
- Rowan Kuiper
- Department of Hematology, Erasmus MC Cancer Institute
- Owen W. Stephens
- Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences
- Uta Bertsch
- Department of Internal Medicine V, University of Heidelberg
- Peter Broderick
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Chiara Campo
- German Cancer Research Center
- Hermann Einsele
- University Clinic of Würzburg
- Walter A. Gregory
- Clinical Trials Research Unit, University of Leeds
- Urban Gullberg
- Department of Laboratory Medicine, Hematology and Transfusion Medicine
- Marc Henrion
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Jens Hillengass
- Department of Internal Medicine V, University of Heidelberg
- Per Hoffmann
- Institute of Human Genetics, University of Bonn
- Graham H. Jackson
- Royal Victoria Infirmary
- Ellinor Johnsson
- Department of Laboratory Medicine, Hematology and Transfusion Medicine
- Magnus Jöud
- Department of Laboratory Medicine, Hematology and Transfusion Medicine
- Sigurður Y. Kristinsson
- Department of Hematology, Landspitali, National University Hospital of Iceland
- Stig Lenhoff
- Hematology Clinic, Skåne University Hospital
- Oleg Lenive
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Ulf-Henrik Mellqvist
- Section of Hematology, Sahlgrenska University Hospital
- Gabriele Migliorini
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Hareth Nahi
- Center for Hematology and Regenerative Medicine, Karolinska Institutet
- Sven Nelander
- Department of Immunology, Rudbeck Laboratory, Pathology and Genetics, Uppsala University
- Jolanta Nickel
- Department of Internal Medicine V, University of Heidelberg
- Markus M. Nöthen
- Institute of Human Genetics, University of Bonn
- Thorunn Rafnar
- deCODE Genetics
- Fiona M. Ross
- Wessex Regional Genetics Laboratory, University of Southampton
- Miguel Inacio da Silva Filho
- German Cancer Research Center
- Bhairavi Swaminathan
- Department of Laboratory Medicine, Hematology and Transfusion Medicine
- Hauke Thomsen
- German Cancer Research Center
- Ingemar Turesson
- Hematology Clinic, Skåne University Hospital
- Annette Vangsted
- Department of Haematology, University Hospital of Copenhagen at Rigshospitalet
- Ulla Vogel
- National Research Centre for the Working Environment
- Anders Waage
- Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology
- Brian A. Walker
- Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences
- Anna-Karin Wihlborg
- Department of Laboratory Medicine, Hematology and Transfusion Medicine
- Annemiek Broyl
- Department of Hematology, Erasmus MC Cancer Institute
- Faith E. Davies
- Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences
- Unnur Thorsteinsdottir
- deCODE Genetics
- Christian Langer
- Department of Internal Medicine III, University of Ulm
- Markus Hansson
- Department of Laboratory Medicine, Hematology and Transfusion Medicine
- Martin Kaiser
- Division of Molecular Pathology, The Institute of Cancer Research
- Pieter Sonneveld
- Department of Hematology, Erasmus MC Cancer Institute
- Kari Stefansson
- deCODE Genetics
- Gareth J. Morgan
- Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences
- Hartmut Goldschmidt
- Department of Internal Medicine V, University of Heidelberg
- Kari Hemminki
- German Cancer Research Center
- Björn Nilsson
- Department of Laboratory Medicine, Hematology and Transfusion Medicine
- Richard S. Houlston
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- DOI
- https://doi.org/10.1038/ncomms12050
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 9
Abstract
Previous genome-wide association studies have identified loci associated with the risk of multiple myeloma. Here, the authors present a meta-analysis of six genome wide association studies of the disease and identify eight new loci; functional studies identify genes as candidates for the basis of these associations.
