A Novel Peptide from <i>Polypedates megacephalus</i> Promotes Wound Healing in Mice
Siqi Fu,
Canwei Du,
Qijian Zhang,
Jiayu Liu,
Xushuang Zhang,
Meichun Deng
Affiliations
Siqi Fu
Hunan Key Laboratory of Medical Epigenomics, Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha 410013, China
Canwei Du
Chengdu Pep Biomedical Co., Ltd., Chengdu 610041, China
Qijian Zhang
Wound Center of Xiangya Hospital, Central South University, Changsha 410013, China
Jiayu Liu
Hunan Province Key Laboratory of Basic and Applied Hematology, Department of Biochemistry and Molecular Biology, School of Life Sciences, Central South University, Changsha 410013, China
Xushuang Zhang
Hunan Province Key Laboratory of Basic and Applied Hematology, Department of Biochemistry and Molecular Biology, School of Life Sciences, Central South University, Changsha 410013, China
Meichun Deng
Hunan Province Key Laboratory of Basic and Applied Hematology, Department of Biochemistry and Molecular Biology, School of Life Sciences, Central South University, Changsha 410013, China
Amphibian skin contains wound-healing peptides, antimicrobial peptides, and insulin-releasing peptides, which give their skin a strong regeneration ability to adapt to a complex and harsh living environment. In the current research, a novel wound-healing promoting peptide, PM-7, was identified from the skin secretions of Polypedates megacephalus, which has an amino acid sequence of FLNWRRILFLKVVR and shares no structural similarity with any peptides described before. It displays the activity of promoting wound healing in mice. Moreover, PM-7 exhibits the function of enhancing proliferation and migration in HUVEC and HSF cells by affecting the MAPK signaling pathway. Considering its favorable traits as a novel peptide that significantly promotes wound healing, PM-7 can be a potential candidate in the development of novel wound-repairing drugs.
