Neuronal Modulators from the Coral-Associated Fungi <i>Aspergillus candidus</i>
Gao-Yang Peng,
Tibor Kurtán,
Attila Mándi,
Jing He,
Zheng-Yu Cao,
Hua Tang,
Shui-Chun Mao,
Wen Zhang
Affiliations
Gao-Yang Peng
School of Pharmacy, Nanchang University, 461 Bayi Road, Nanchang 330006, China
Tibor Kurtán
Department of Organic Chemistry, University of Debrecen, POB 400, H-4002 Debrecen, Hungary
Attila Mándi
Department of Organic Chemistry, University of Debrecen, POB 400, H-4002 Debrecen, Hungary
Jing He
State Key Laboratory of Natural Medicines, Department of TCM Pharmacology, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Long-Mian Ave., Nanjing 211198, China
Zheng-Yu Cao
State Key Laboratory of Natural Medicines, Department of TCM Pharmacology, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Long-Mian Ave., Nanjing 211198, China
Hua Tang
Institute of Translational Medicine, Shanghai University, 99 Shang-Da Road, Shanghai 200444, China
Shui-Chun Mao
School of Pharmacy, Nanchang University, 461 Bayi Road, Nanchang 330006, China
Wen Zhang
School of Medicine, Tongji University, 1239 Si-Ping Road, Shanghai 200092, China
Three new p-terphenyl derivatives, named 4″-O-methyl-prenylterphenyllin B (1) and phenylcandilide A and B (17 and 18), and three new indole-diterpene alkaloids, asperindoles E–G (22-24), were isolated together with eighteen known analogues from the fungi Aspergillus candidus associated with the South China Sea gorgonian Junceela fragillis. The structures and absolute configurations of the new compounds were elucidated on the basis of spectroscopic analysis, and DFT/NMR and TDDFT/ECD calculations. In a primary cultured cortical neuronal network, the compounds 6, 9, 14, 17, 18 and 24 modulated spontaneous Ca2+ oscillations and 4-aminopyridine hyperexcited neuronal activity. A preliminary structure–activity relationship was discussed.
