ASSOCIATION BETWEEN HANDGRIP STRENGTH AND INFLAMMATION IN HEMODIALYSIS PATIENTS

Abstract

The inflammation is a common feature in HD patients and may contribute to muscle wasting. Handgrip strength (HGS) has been recognized as a useful tool in assessing muscle function in hemodialysis (HD) patients. The aim of this study was to evaluate the association between inflammation and muscle function in HD patients. Twenty-three HD patients (19 men, 54.3±12.4 years of age, BMI, 24.5±4.6kg/m2) were studied. HGS was measured 3x with a mechanical dynamometer after the HD sessions. HGS values less than the 10th percentile of an age-, gender- and regional specific reference were considered as muscle function loss. Tumoral necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were determined by a multiplex assay kit through the device Luminex method. C-reactive protein (CRP) was measured with the immunoturbidimetric method. HGS values were significantly greater in males (28.8±9.7 kg) than females (13.9±6.5kg) (p 0.3mg/dL). CRP and IL-6 were not correlated with HGS, but TNF-α were inversely correlated with HGS (r =-0.42; p = 0.01). These data suggest that inflammation can play an important role on muscle function in HD patients.fx1