Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization

Abstract

The selective formation of protein bioconjugates under physiological conditions is a challenging task. Here, the authors report that 1,4-dinitroimidazoles are reagents of choice for protein bioconjugation at either cysteine or lysine sites within short times and provide facile access to peptide macrocycles.