Toxicon: X (Jan 2019)

Third-generation antivenomics analysis of the preclinical efficacy of Bothrofav® antivenom towards Bothrops lanceolatus venom

  • Davinia Pla,
  • Yania Rodríguez,
  • Dabor Resiere,
  • Hossein Mehdaoui,
  • José María Gutiérrez,
  • Juan J. Calvete

Journal volume & issue
Vol. 1

Abstract

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Bothrops lanceolatus inflicts severe envenomings in the Lesser Caribbean island of Martinique. Bothrofav®, a monospecific antivenom against B. lanceolatus venom, has proven highly effective at the preclinical and clinical levels. Here, we report a detailed third-generation antivenomics quantitative analysis of Bothrofav®. With the exception of poorly-immunogenic peptides, Bothrofav® immunocaptured all the major protein components. These results, along with previous preclinical and clinical observations, underscore the high neutralizing efficacy of the antivenom against B. lanceolatus venom. Keywords: Bothrops lanceolatus, Antivenom, Snake venom, Bothrofav®, Third-generation antivenomics, Martinique