Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1

Abstract

It is unclear how removal of axon debris and initiation of axon regeneration following nerve injury is co-regulated. In this study, the authors show that the extracellular domain (ECD) of the engulfment receptor, CED-1, functions as an adhesion molecule to promote axonal regeneration after injury, independent of its function in phagocytosis