Evaluation of Risk Factors for Acute Coronary Syndrome in Patients Referring to the Cardiology Clinic of Shahid Beheshti Hospital in Qom City, 2015, Iran

Abstract

Background and Objectives: Cardiovascular diseases are one of the most common causes of fatal diseases in the world. Alterations in biochemical composition of blood plasma are associated with coronary heart disease. In this study, some biochemical markers were investigated in patients suspicious to coronary artery disease (CAD) without acute coronary syndrome symptoms. Methods: In this descriptive cross-sectional study, 120 patients suspicious to CAD, were ivestigated. In all of them, physical examinations were performed and biochemical parameters, were measured. The patients were divided into CAD-positive and -negative groups, and their biochemical markers were compared. Results: CAD-positive cases, was significantly associated with Troponin, ESR, and Helicobacter pylori-Positive serology. A significant association was found between age, male gender, BMI, and positive CAD. ESR sensitivity, specificity, positive and negative predictive values and positive and negative likelihood ratio for diagnosis of CAD, were 56.5%, 65.5%, 63.6%, 58.5%, 1.61, and 0.66, respectively. Also, Troponin sensitivity, specificity, positive and negative predictive values, and positive and negative LR, were 18%, 96.5%, 84.5%, 52.3%, 5.2, and 0.85, respectively. A positive correlation was found between Helicobacter pylori-positive serology and CAD-positive cases (1.48-10, CI=95%, OR=3.86, p=0.006). Conclusion: Based on the findings of the present research, in patients without acute coronary syndrome symptom, only ESR>10mm/h, positive cTnI, and Helicobacter pylori-positive serology had different results between the patients with and without CAD, which can be suggestive of CAD in asymptomatic cases.

Keywords

• coronary artery disease
• biomarkers
• asymptomatic disease