Communications Biology (Mar 2023)
Deep genomic characterization highlights complexities and prognostic markers of pediatric acute myeloid leukemia
- Chi-Keung Cheng,
- Yuk-Lin Yung,
- Hoi-Yun Chan,
- Kam-Tong Leung,
- Kathy Y. Y. Chan,
- Alex W. K. Leung,
- Frankie W. T. Cheng,
- Chi-Kong Li,
- Thomas S. K. Wan,
- Xi Luo,
- Herbert-Augustus Pitts,
- Joyce S. Cheung,
- Natalie P. H. Chan,
- Margaret H. L. Ng
Affiliations
- Chi-Keung Cheng
- Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong
- Yuk-Lin Yung
- Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong
- Hoi-Yun Chan
- Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong
- Kam-Tong Leung
- Department of Paediatrics, The Chinese University of Hong Kong
- Kathy Y. Y. Chan
- Department of Paediatrics, The Chinese University of Hong Kong
- Alex W. K. Leung
- Department of Paediatrics, The Chinese University of Hong Kong
- Frankie W. T. Cheng
- Department of Paediatrics, The Chinese University of Hong Kong
- Chi-Kong Li
- Department of Paediatrics, The Chinese University of Hong Kong
- Thomas S. K. Wan
- Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong
- Xi Luo
- Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong
- Herbert-Augustus Pitts
- Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong
- Joyce S. Cheung
- Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong
- Natalie P. H. Chan
- Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong
- Margaret H. L. Ng
- Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong
- DOI
- https://doi.org/10.1038/s42003-023-04732-2
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 16
Abstract
A genomic analysis of 147 pediatric acute myeloid leukemia patients identifies extensive gene fusion events and mutations that expand our understanding of the genetic complexities of this cancer.
