Nature Communications (Oct 2020)
Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits
- Julia Böhme,
- Nuria Martinez,
- Shamin Li,
- Andrea Lee,
- Mardiana Marzuki,
- Anteneh Mehari Tizazu,
- David Ackart,
- Jessica Haugen Frenkel,
- Alexandra Todd,
- Ekta Lachmandas,
- Josephine Lum,
- Foo Shihui,
- Tze Pin Ng,
- Bernett Lee,
- Anis Larbi,
- Mihai G. Netea,
- Randall Basaraba,
- Reinout van Crevel,
- Evan Newell,
- Hardy Kornfeld,
- Amit Singhal
Affiliations
- Julia Böhme
- Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)
- Nuria Martinez
- Department of Medicine, University of Massachusetts Medical School
- Shamin Li
- Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)
- Andrea Lee
- Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)
- Mardiana Marzuki
- Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)
- Anteneh Mehari Tizazu
- Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)
- David Ackart
- Department of Microbiology, Immunology & Pathology, Colorado State University
- Jessica Haugen Frenkel
- Department of Microbiology, Immunology & Pathology, Colorado State University
- Alexandra Todd
- Department of Microbiology, Immunology & Pathology, Colorado State University
- Ekta Lachmandas
- Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center
- Josephine Lum
- Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)
- Foo Shihui
- Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)
- Tze Pin Ng
- Gerontology Research Programme, Yong Loo Lin School of Medicine, Department of Psychological Medicine, National University Health System, National University of Singapore
- Bernett Lee
- Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)
- Anis Larbi
- Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)
- Mihai G. Netea
- Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center
- Randall Basaraba
- Department of Microbiology, Immunology & Pathology, Colorado State University
- Reinout van Crevel
- Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center
- Evan Newell
- Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)
- Hardy Kornfeld
- Department of Medicine, University of Massachusetts Medical School
- Amit Singhal
- Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)
- DOI
- https://doi.org/10.1038/s41467-020-19095-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Metformin is an anti-diabetic drug that has shown promise to reduce M. tuberculosis susceptibility. Here the authors show that this effect is a result of metformin-mediated activation of anti-mycobacterial memory-like antigen-inexperienced CD8+CXCR3+ T cells, an effect that also boosts response to BCG vaccination.
