Communications Biology (Nov 2022)

Matching amino acids membrane preference profile to improve activity of antimicrobial peptides

  • Shanghyeon Kim,
  • Jaehoo Lee,
  • Sol Lee,
  • Hyein Kim,
  • Ji-Yeong Sim,
  • Boryeong Pak,
  • Kyeongmin Kim,
  • Jae Il Kim

DOI
https://doi.org/10.1038/s42003-022-04164-4
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 13

Abstract

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Canonical helical antimicrobial peptides are less insertive and less active. Here, an improved antimicrobial peptide, WCopWs, indicate that matching amino acids membrane preference profile improves insertion and activity.