The pleiotropic effects of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in renal disease

Abstract

Sabas I Gomez,1 Christos G Mihos,2 Andres M Pineda,2 Orlando Santana21Department of Internal Medicine, Mount Sinai Medical Center, 2Columbia University Division of Cardiology, Mount Sinai Heart Institute, Miami Beach, FL, USAAbstract: It is well known that statins exert their main effect by inhibiting cholesterol synthesis through the inhibition of the 3-hydroxy-3-methyl-glutaryl-CoA reductase enzyme. The pleiotropic effects of statins, which are independent of their inhibition of cholesterol synthesis, have explained many of the beneficial effects of these drugs in a variety of disorders such as malignancies, infection, and sepsis, as well as in cardiovascular and rheumatologic disorders. However, the role of these drugs in renal disorders remains controversial. In the present review, we examine the most recent findings involving statins and renal disease among different clinical scenarios, including chronic kidney disease, contrast-induced nephropathy, renal injury after coronary artery bypass surgery, and renal transplant patients.Keywords: kidney disease, statins, renal transplant