Nature Communications (Nov 2022)
HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex
- Matthias S. Leisegang,
- Jasleen Kaur Bains,
- Sandra Seredinski,
- James A. Oo,
- Nina M. Krause,
- Chao-Chung Kuo,
- Stefan Günther,
- Nevcin Sentürk Cetin,
- Timothy Warwick,
- Can Cao,
- Frederike Boos,
- Judit Izquierdo Ponce,
- Shaza Haydar,
- Rebecca Bednarz,
- Chanil Valasarajan,
- Dominik C. Fuhrmann,
- Jens Preussner,
- Mario Looso,
- Soni S. Pullamsetti,
- Marcel H. Schulz,
- Hendrik R. A. Jonker,
- Christian Richter,
- Flávia Rezende,
- Ralf Gilsbach,
- Beatrice Pflüger-Müller,
- Ilka Wittig,
- Ingrid Grummt,
- Teodora Ribarska,
- Ivan G. Costa,
- Harald Schwalbe,
- Ralf P. Brandes
Affiliations
- Matthias S. Leisegang
- Institute for Cardiovascular Physiology, Goethe University
- Jasleen Kaur Bains
- Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe University
- Sandra Seredinski
- Institute for Cardiovascular Physiology, Goethe University
- James A. Oo
- Institute for Cardiovascular Physiology, Goethe University
- Nina M. Krause
- Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe University
- Chao-Chung Kuo
- Institute for Computational Genomics, Joint Research Center for Computational Biomedicine, RWTH Aachen Medical Faculty
- Stefan Günther
- Max Planck Institute for Heart and Lung Research
- Nevcin Sentürk Cetin
- Division of Molecular Biology of the Cell II, German Cancer Research Center DKFZ-ZMBH
- Timothy Warwick
- Institute for Cardiovascular Physiology, Goethe University
- Can Cao
- Institute for Cardiovascular Physiology, Goethe University
- Frederike Boos
- Institute for Cardiovascular Physiology, Goethe University
- Judit Izquierdo Ponce
- Institute for Cardiovascular Physiology, Goethe University
- Shaza Haydar
- Institute for Cardiovascular Physiology, Goethe University
- Rebecca Bednarz
- Institute for Cardiovascular Physiology, Goethe University
- Chanil Valasarajan
- Max Planck Institute for Heart and Lung Research
- Dominik C. Fuhrmann
- Faculty of Medicine, Institute of Biochemistry I, Goethe University
- Jens Preussner
- Max Planck Institute for Heart and Lung Research
- Mario Looso
- Max Planck Institute for Heart and Lung Research
- Soni S. Pullamsetti
- Max Planck Institute for Heart and Lung Research
- Marcel H. Schulz
- German Center of Cardiovascular Research (DZHK), Partner site RheinMain
- Hendrik R. A. Jonker
- Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe University
- Christian Richter
- Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe University
- Flávia Rezende
- Institute for Cardiovascular Physiology, Goethe University
- Ralf Gilsbach
- Institute for Cardiovascular Physiology, Goethe University
- Beatrice Pflüger-Müller
- Institute for Cardiovascular Physiology, Goethe University
- Ilka Wittig
- Institute for Cardiovascular Physiology, Goethe University
- Ingrid Grummt
- Division of Molecular Biology of the Cell II, German Cancer Research Center DKFZ-ZMBH
- Teodora Ribarska
- Division of Molecular Biology of the Cell II, German Cancer Research Center DKFZ-ZMBH
- Ivan G. Costa
- Institute for Computational Genomics, Joint Research Center for Computational Biomedicine, RWTH Aachen Medical Faculty
- Harald Schwalbe
- Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe University
- Ralf P. Brandes
- Institute for Cardiovascular Physiology, Goethe University
- DOI
- https://doi.org/10.1038/s41467-022-34252-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 20
Abstract
Using a composite bioinformatics approach, the DNA:DNA:RNA triplex-forming lncRNAs HIF1α-AS1 was identified in human endothelial cells which recruits an epigenetic silencing complex to limit expression of triplex target genes.
