Functions of GSK-3 signaling in development of the nervous system.

Abstract

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GSK-3 is central to multiple intracellular pathways including those activated by Wnt/beta-catenin, Sonic Hedgehog, Notch, growth factor/RTK, and G protein-coupled receptor signals. All of these signals importantly contribute to neural development. Early attention on GSK-3 signaling in neural development centered on the regulation of neuronal polarity using in vitro paradigms. However, recent creation of appropriate genetic models has demonstrated the importance of GSK-3 to multiple aspects of neural development including neural progenitor self-renewal, neurogenesis, neuronal migration, neural differentiation, and synaptic development.

Keywords

• Neural progenitor
• neuronal migration
• neural differentiation
• synaptic development
• GSK-3