Saccharobisindole, Neoasterric Methyl Ester, and 7-Chloro-4(1H)-quinolone: Three New Compounds Isolated from the Marine Bacterium <i>Saccharomonospora</i> sp.
Sohee Kim,
Tu Cam Le,
Sang-Ah Han,
Prima F. Hillman,
Ahreum Hong,
Sunghoon Hwang,
Young Eun Du,
Hiyoung Kim,
Dong-Chan Oh,
Sun-Shin Cha,
Jihye Lee,
Sang-Jip Nam,
William Fenical
Affiliations
Sohee Kim
The Graduate School of Industrial Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea
Tu Cam Le
Laboratory of Advanced Materials Chemistry, Advanced Institute of Materials Science, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam
Sang-Ah Han
The Graduate School of Industrial Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea
Prima F. Hillman
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea
Ahreum Hong
The Graduate School of Industrial Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea
Sunghoon Hwang
Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea
Young Eun Du
Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea
Hiyoung Kim
Department of Biomedical Science and Engineering, Konkuk University, Seoul 05029, Korea
Dong-Chan Oh
Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea
Sun-Shin Cha
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea
Jihye Lee
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea
Sang-Jip Nam
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea
William Fenical
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, CA 92093-0204, USA
Analysis of the chemical components from the culture broth of the marine bacterium Saccharomonospora sp. CNQ-490 has yielded three novel compounds: saccharobisindole (1), neoasterric methyl ester (2), and 7-chloro-4(1H)-quinolone (3), in addition to acremonidine E (4), pinselin (5), penicitrinon A (6), and penicitrinon E (7). The chemical structures of the three novel compounds were elucidated by the interpretation of 1D, 2D nuclear magnetic resonance (NMR), and high-resolution mass spectrometry (HRMS) data. Compound 2 generated weak inhibition activity against Bacillus subtilis KCTC2441 and Staphylococcus aureus KCTC1927 at concentrations of 32 μg/mL and 64 μg/mL, respectively, whereas compounds 1 and 3 did not have any observable effects. In addition, compound 2 displayed weak anti-quorum sensing (QS) effects against S. aureus KCTC1927 and Micrococcus luteus SCO560.
