Marine Drugs (Dec 2021)

Saccharobisindole, Neoasterric Methyl Ester, and 7-Chloro-4(1H)-quinolone: Three New Compounds Isolated from the Marine Bacterium <i>Saccharomonospora</i> sp.

  • Sohee Kim,
  • Tu Cam Le,
  • Sang-Ah Han,
  • Prima F. Hillman,
  • Ahreum Hong,
  • Sunghoon Hwang,
  • Young Eun Du,
  • Hiyoung Kim,
  • Dong-Chan Oh,
  • Sun-Shin Cha,
  • Jihye Lee,
  • Sang-Jip Nam,
  • William Fenical

DOI
https://doi.org/10.3390/md20010035
Journal volume & issue
Vol. 20, no. 1
p. 35

Abstract

Read online

Analysis of the chemical components from the culture broth of the marine bacterium Saccharomonospora sp. CNQ-490 has yielded three novel compounds: saccharobisindole (1), neoasterric methyl ester (2), and 7-chloro-4(1H)-quinolone (3), in addition to acremonidine E (4), pinselin (5), penicitrinon A (6), and penicitrinon E (7). The chemical structures of the three novel compounds were elucidated by the interpretation of 1D, 2D nuclear magnetic resonance (NMR), and high-resolution mass spectrometry (HRMS) data. Compound 2 generated weak inhibition activity against Bacillus subtilis KCTC2441 and Staphylococcus aureus KCTC1927 at concentrations of 32 μg/mL and 64 μg/mL, respectively, whereas compounds 1 and 3 did not have any observable effects. In addition, compound 2 displayed weak anti-quorum sensing (QS) effects against S. aureus KCTC1927 and Micrococcus luteus SCO560.

Keywords