Changes in Clinical Characteristics of Community-Acquired Acute Pyelonephritis and Antimicrobial Resistance of Uropathogenic <i>Escherichia coli</i> in South Korea in the Past Decade
Ki Tae Kwon,
Bongyoung Kim,
Seong-yeol Ryu,
Seong-Heon Wie,
Jieun Kim,
Hyun-uk Jo,
Se Yoon Park,
Kyung-Wook Hong,
Hye In Kim,
Hyun ah Kim,
Mi-Hee Kim,
Mi Hyun Bae,
Yong-Hak Sohn,
Jieun Kim,
Yangsoon Lee,
Hyunjoo Pai
Affiliations
Ki Tae Kwon
Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 41566, Korea
Bongyoung Kim
Department of Internal Medicine, College of Medicine, Hanyang University, Seoul 04763, Korea
Seong-yeol Ryu
Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu 41931, Korea
Seong-Heon Wie
Division of Infectious Diseases, Department of Internal Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
Jieun Kim
Department of Internal Medicine, College of Medicine, Hanyang University, Seoul 04763, Korea
Hyun-uk Jo
Department of Urology, School of Medicine, Eulji University, Daejeon 34824, Korea
Se Yoon Park
Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul 04401, Korea
Kyung-Wook Hong
Division of Infectious Diseases, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju 52727, Korea
Hye In Kim
Department of Internal Meidcine, Daegu Fatima Hospital, Daegu 41199, Korea
Hyun ah Kim
Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu 41931, Korea
Mi-Hee Kim
Division of Infectious Diseases, Department of Internal Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
Mi Hyun Bae
Department of Laboratory Medicine, College of Medicine, Hanyang University, Seoul 04763, Korea
Yong-Hak Sohn
Seegene Medical Foundation, Seoul 04805, Korea
Jieun Kim
Department of Laboratory Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul 04401, Korea
Yangsoon Lee
Department of Laboratory Medicine, College of Medicine, Hanyang University, Seoul 04763, Korea
Hyunjoo Pai
Department of Internal Medicine, College of Medicine, Hanyang University, Seoul 04763, Korea
This study examined changes in the clinical characteristics of community-acquired acute pyelonephritis (CA-APN) in South Korea between the period 2010–2011 and 2017–2018. We recruited all CA-APN patients aged ≥19 years who visited eight hospitals in South Korea from September 2017 to August 2018, prospectively. Data collected were compared with those from the previous study in 2010–2012, with the same design and participation from 11 hospitals. A total of 617 patients were enrolled and compared to 818 patients’ data collected in 2010–2011. Escherichia coli was the most common causative pathogen of CA-APN in both periods (87.3% vs. 86.5%, p = 0.680). E. coli isolates showed significantly higher antimicrobial resistance against fluoroquinolone (32.0% vs. 21.6%, p p p = 0.013) in 2017–2018 than in 2010–2011. Total duration of antibiotic treatment increased from 16.55 ± 9.68 days in 2010–2011 to 19.12 ± 9.90 days in 2017–2018 (p p p E. coli to almost all antibiotic classes, especially third generation cephalosporin, increased significantly in CA-APN in South Korea. Consequently, total duration of antibiotic treatment, including carbapenem usage, increased.
