Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer

Liyuan Zhou; Qiongzi Qiu; Qing Zhou; Jianwei Li; Mengqian Yu; Kezhen Li; Lingling Xu; Xiaohui Ke; Haiming Xu; Bingjian Lu; Hui Wang; Weiguo Lu; Pengyuan Liu; Yan Lu

doi:10.1038/s41467-022-30190-1

Nature Communications (May 2022)

Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer

Liyuan Zhou,
Qiongzi Qiu,
Qing Zhou,
Jianwei Li,
Mengqian Yu,
Kezhen Li,
Lingling Xu,
Xiaohui Ke,
Haiming Xu,
Bingjian Lu,
Hui Wang,
Weiguo Lu,
Pengyuan Liu,
Yan Lu

Affiliations

Liyuan Zhou: Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Qiongzi Qiu: Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women’s Hospital, Zhejiang University School of Medicine
Qing Zhou: Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women’s Hospital, Zhejiang University School of Medicine
Jianwei Li: Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women’s Hospital, Zhejiang University School of Medicine
Mengqian Yu: Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Kezhen Li: Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lingling Xu: Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Xiaohui Ke: Department of Obstetrics and Gynecology, Wenzhou Central Hospital
Haiming Xu: Institute of Bioinformatics, Zhejiang University
Bingjian Lu: Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women’s Hospital, Zhejiang University School of Medicine
Hui Wang: Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women’s Hospital, Zhejiang University School of Medicine
Weiguo Lu: Cancer center, Zhejiang University
Pengyuan Liu: Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Yan Lu: Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women’s Hospital, Zhejiang University School of Medicine

DOI: https://doi.org/10.1038/s41467-022-30190-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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The molecular mechanisms underlying cervical carcinogenesis following integration of HPV DNA into the human genome remain elusive. Here, the authors perform long-read sequencing in 16 HPV16-positive cervical tumors and identify distinct integration types, structural variations and potential driver genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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