Methicillin-resistant Staphylococcus aureus bacteremia with elevated vancomycin minimum inhibitory concentrations

Alexandra G. Mills; Amy C. Dupper; Kieran I. Chacko; Bremy Alburquerque; Devika Nadkarni; Ana Berbel Caban; Lindsey Fox; Melissa R. Gitman; Ajay Obla; Harm van Bakel; Deena R. Altman

doi:10.1017/ash.2023.163

Antimicrobial Stewardship & Healthcare Epidemiology (Jan 2023)

Methicillin-resistant Staphylococcus aureus bacteremia with elevated vancomycin minimum inhibitory concentrations

Alexandra G. Mills,
Amy C. Dupper,
Kieran I. Chacko,
Bremy Alburquerque,
Devika Nadkarni,
Ana Berbel Caban,
Lindsey Fox,
Melissa R. Gitman,
Ajay Obla,
Harm van Bakel,
Deena R. Altman

Affiliations

Alexandra G. Mills: ORCiD; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York
Amy C. Dupper: Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York
Kieran I. Chacko: ORCiD; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, New York
Bremy Alburquerque: ORCiD; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, New York
Devika Nadkarni: Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York
Ana Berbel Caban: ORCiD; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York
Lindsey Fox: Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York
Melissa R. Gitman: ORCiD; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York
Ajay Obla: ORCiD; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, New York
Harm van Bakel: ORCiD; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, New York Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, New York
Deena R. Altman: ORCiD; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, New York

DOI: https://doi.org/10.1017/ash.2023.163
Journal volume & issue: Vol. 3

Abstract

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This case–control study of 25 cases with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia with vancomycin minimum inhibitory concentration (MIC) ≥ 2 µg/mL and 391 controls (MIC < 2 µg/mL) characterized the clinical characteristics, treatments, and outcomes associated with elevated vancomycin MIC. Elevated vancomycin MIC was associated with baseline hemodialysis, prior MRSA colonization, and metastatic infection.

Published in Antimicrobial Stewardship & Healthcare Epidemiology

ISSN: 2732-494X (Online)
Publisher: Cambridge University Press
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Medicine: Public aspects of medicine
Website: https://www.cambridge.org/core/journals/antimicrobial-stewardship-and-healthcare-epidemiology

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