Specific features of immunity in neonatal infants with localized and generalized bacterial infections

Abstract

Cellular immunity indicators were investigated in infants with localized (и=10) and generalized (и=15) bacterial infections (sepsis). The blood levels of different groups of white blood cells (neutrophils, lymphocytes, monocytes) and lymphocyte subpopulations (CD3, CD4, CD8, CD16/56, and CD19) were estimated. The development of sepsis was accompanied by leukocytosis and leukopenia in 47 and 20% of the cases, respectively. In localized infections, there was leukocytosis in 30% of the infants and leukopenia in 10%. Absolute lymphopenia was present in 40% of the cases of sepsis and in 20% of those of localized infections. The acute period of neonatal sepsis was accompanied by a substantial reduction in the level of CD3+, CD4+, CD8+, and CD16/56+ lymphocyte subpopulations. The highest changes were recorded in the CD4+ and CD16/56+: their counts were decreased by an average of 3,9 and 3,6 times, respectively, compared to the control values; CD8+ lymphocytes dropped by 2,7 times. Localized infections were characterized by a predominant fall in the number of CD4+ and CD16/56+ subpopulations. Moreover, the level of CD4+ lymphocytes was significantly lower than that in the sepsis group. Thus, the acute period of both localized and generalized bacterial infections took place in the presence of cellular immunity suppression. The most marked changes were recorded in sepsis. The fi

Keywords

• дети
• неонатальный сепсис
• иммунный статус.