npj Microgravity (May 2024)
How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?
- Craig R. G. Willis,
- Marco Calvaruso,
- Debora Angeloni,
- Sarah Baatout,
- Alexandra Benchoua,
- Juergen Bereiter-Hahn,
- Daniele Bottai,
- Judith-Irina Buchheim,
- Eugénie Carnero-Diaz,
- Sara Castiglioni,
- Duccio Cavalieri,
- Gabriele Ceccarelli,
- Alexander Chouker,
- Francesca Cialdai,
- Gianni Ciofani,
- Giuseppe Coppola,
- Gabriella Cusella,
- Andrea Degl’Innocenti,
- Jean-Francois Desaphy,
- Jean-Pol Frippiat,
- Michael Gelinsky,
- Giada Genchi,
- Maria Grano,
- Daniela Grimm,
- Alain Guignandon,
- Raúl Herranz,
- Christine Hellweg,
- Carlo Saverio Iorio,
- Thodoris Karapantsios,
- Jack van Loon,
- Matteo Lulli,
- Jeanette Maier,
- Jos Malda,
- Emina Mamaca,
- Lucia Morbidelli,
- Andreas Osterman,
- Aleksandr Ovsianikov,
- Francesco Pampaloni,
- Elizabeth Pavezlorie,
- Veronica Pereda-Campos,
- Cyrille Przybyla,
- Petra Rettberg,
- Angela Maria Rizzo,
- Kate Robson-Brown,
- Leonardo Rossi,
- Giorgio Russo,
- Alessandra Salvetti,
- Chiara Risaliti,
- Daniela Santucci,
- Matthias Sperl,
- Kevin Tabury,
- Sara Tavella,
- Christiane Thielemann,
- Ronnie Willaert,
- Monica Monici,
- Nathaniel J. Szewczyk
Affiliations
- Craig R. G. Willis
- School of Chemistry and Biosciences, Faculty of Life Sciences, University of Bradford
- Marco Calvaruso
- Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR)
- Debora Angeloni
- Institute of Biorobotics, Scuola Superiore Sant’Anna
- Sarah Baatout
- Laboratory of Radiobiology, Belgian Nuclear Research Centre, SCK CEN
- Alexandra Benchoua
- ISTEM, CECS, AFM-Téléthon
- Juergen Bereiter-Hahn
- Institute for Cell and Neurobiol. Goethe University Frankfurt am Main
- Daniele Bottai
- Department of Pharmaceutical Sciences, University of Milan
- Judith-Irina Buchheim
- Laboratory “Translational Research, Stress & Immunity”, LMU University Hospital Munich
- Eugénie Carnero-Diaz
- Institute Systematic, Evolution, Biodiversity, Sorbonne University, NMNH, CNRS, EPHE, UA
- Sara Castiglioni
- Department of Biomedical and Clinical Sciences, University of Milan
- Duccio Cavalieri
- Department of Biology, University of Florence
- Gabriele Ceccarelli
- Department of Public Health, Experimental Medicine and Forensic, University of Pavia
- Alexander Chouker
- Laboratory “Translational Research, Stress & Immunity”, LMU University Hospital Munich
- Francesca Cialdai
- ASAcampus Joint Laboratory, ASA Res. Div., DSBSC-University of Florence
- Gianni Ciofani
- Smart Bio-Interfaces, Istituto Italiano di Tecnologia
- Giuseppe Coppola
- Institue of Applied Science and Intelligent Sistems – CNR
- Gabriella Cusella
- Department of Public Health, Experimental Medicine and Forensic, University of Pavia
- Andrea Degl’Innocenti
- Smart Bio-Interfaces, Istituto Italiano di Tecnologia
- Jean-Francois Desaphy
- Department of Precision and Regenerative Medicine, University of Bari “Aldo Moro”
- Jean-Pol Frippiat
- Stress, Immunity, Pathogens Laboratory, SIMPA, Université de Lorraine
- Michael Gelinsky
- Centre for Translational Bone, Joint & Soft Tissue Research, TU Dresden
- Giada Genchi
- Smart Bio-Interfaces, Istituto Italiano di Tecnologia
- Maria Grano
- Department of Precision and Regenerative Medicine, University of Bari “Aldo Moro”
- Daniela Grimm
- Department of Microgravity and Translational Regenerative Medicine, Otto-von-Guericke-University Magdeburg
- Alain Guignandon
- SAINBIOSE, INSERM U1059, Université Jean Monnet
- Raúl Herranz
- Centro de Investigaciones Biológicas Margarita Salas (CSIC)
- Christine Hellweg
- Radiation Biology Dept., Inst. of Aerospace Medicine, German Aerospace Center (DLR)
- Carlo Saverio Iorio
- CREST-ATM, Université libre de Bruxelles
- Thodoris Karapantsios
- Faculty of Chemistry, Aristotle Univeristy of Thessaloniki
- Jack van Loon
- Amsterdam University Medical Center, ACTA/VU
- Matteo Lulli
- Department of Experimental and Clinical Biomedical Sciences, University of Florence
- Jeanette Maier
- Department of Biomedical and Clinical Sciences, University of Milan
- Jos Malda
- Department of Orthopaedics, Univ. Med. Center Utrecht & Dept. Clinical Sciences, Utrecht Univ
- Emina Mamaca
- European and International Affairs Dept, Ifremer centre Bretagne
- Lucia Morbidelli
- Department of Life Sciences, Univ. of Siena
- Andreas Osterman
- Max von Pettenkofer Institute, Virology, LMU Munich & DZIF, Partner Site Munich
- Aleksandr Ovsianikov
- 3D Printing and Biofabrication, Inst. Materials Science and Technology, TU Wien
- Francesco Pampaloni
- Buchmann Inst. for Molecular Life Sciences, Goethe-Universität Frankfurt am Main
- Elizabeth Pavezlorie
- Ludwig Boltzmann Inst. for Traumatology, Res. Center in Cooperation with AUVA
- Veronica Pereda-Campos
- GSBMS/URU EVOLSAN - Medecine Evolutive, Université Paul Sabatier Toulouse III
- Cyrille Przybyla
- MARBEC, Univ Montpellier, CNRS, Ifremer, IRD
- Petra Rettberg
- DLR, Institute of Aerospace Medicine, Research Group Astrobiology
- Angela Maria Rizzo
- Department of Pharmacological and Biomolecular Sciences, University of Milan
- Kate Robson-Brown
- Department of Engineering Mathematics, and Dept of Anthropology and Archaeology, University of Bristol
- Leonardo Rossi
- Department of Clinical and Experimental Medicine, University of Pisa
- Giorgio Russo
- Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR)
- Alessandra Salvetti
- Department of Clinical and Experimental Medicine, University of Pisa
- Chiara Risaliti
- ASAcampus Joint Laboratory, ASA Res. Div., DSBSC-University of Florence
- Daniela Santucci
- Center for Behavioural Sciences and Mental Health, Ist. Superiore Sanità
- Matthias Sperl
- DLR-MP
- Kevin Tabury
- Laboratory of Radiobiology, Belgian Nuclear Research Centre, SCK CEN
- Sara Tavella
- IRCCS Ospedale Policlinico San Martino and University of Genoa, DIMES
- Christiane Thielemann
- BioMEMS Lab, University of Applied Sciences Aschaffenburg
- Ronnie Willaert
- Research Group NAMI and NANO, Vrije Universiteit Brussels
- Monica Monici
- ASAcampus Joint Laboratory, ASA Res. Div., DSBSC-University of Florence
- Nathaniel J. Szewczyk
- Heritage College of Osteopathic Medicine, Ohio University
- DOI
- https://doi.org/10.1038/s41526-024-00395-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 5
Abstract
Abstract Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, “Biology in Space and Analogue Environments”, focusses in 5 main topic areas, aiming to address key community-identified knowledge gaps in Space Biology. Here we present one of the identified topic areas, which is also an unanswered question of life science research in Space: “How to Obtain an Integrated Picture of the Molecular Networks Involved in Adaptation to Microgravity in Different Biological Systems?” The manuscript reports the main gaps of knowledge which have been identified by the community in the above topic area as well as the approach the community indicates to address the gaps not yet bridged. Moreover, the relevance that these research activities might have for the space exploration programs and also for application in industrial and technological fields on Earth is briefly discussed.
