Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System Atrophy

Akio Kikuchi; Atsushi Takeda; Hiroshi Onodera; Teiko Kimpara; Kinya Hisanaga; Nobuyuki Sato; Akihiko Nunomura; Rudy J. Castellani; George Perry; Mark A. Smith; Yasuto Itoyama

Neurobiology of Disease (Mar 2002)

Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System Atrophy

Akio Kikuchi,
Atsushi Takeda,
Hiroshi Onodera,
Teiko Kimpara,
Kinya Hisanaga,
Nobuyuki Sato,
Akihiko Nunomura,
Rudy J. Castellani,
George Perry,
Mark A. Smith,
Yasuto Itoyama

Affiliations

Akio Kikuchi: Department of Neurology, Tohoku University School of Medicine, Sendai, Japan; Department of Neurology, Nishitaga National Hospital, Sendai, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan; Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa, Japan; Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, Ohio
Atsushi Takeda: Department of Neurology, Tohoku University School of Medicine, Sendai, Japan; Department of Neurology, Nishitaga National Hospital, Sendai, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan; Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa, Japan; Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, Ohio
Hiroshi Onodera: Department of Neurology, Tohoku University School of Medicine, Sendai, Japan; Department of Neurology, Nishitaga National Hospital, Sendai, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan; Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa, Japan; Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, Ohio
Teiko Kimpara: Department of Neurology, Tohoku University School of Medicine, Sendai, Japan; Department of Neurology, Nishitaga National Hospital, Sendai, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan; Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa, Japan; Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, Ohio
Kinya Hisanaga: Department of Neurology, Tohoku University School of Medicine, Sendai, Japan; Department of Neurology, Nishitaga National Hospital, Sendai, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan; Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa, Japan; Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, Ohio
Nobuyuki Sato: Department of Neurology, Tohoku University School of Medicine, Sendai, Japan; Department of Neurology, Nishitaga National Hospital, Sendai, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan; Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa, Japan; Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, Ohio
Akihiko Nunomura: Department of Neurology, Tohoku University School of Medicine, Sendai, Japan; Department of Neurology, Nishitaga National Hospital, Sendai, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan; Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa, Japan; Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, Ohio
Rudy J. Castellani: Department of Neurology, Tohoku University School of Medicine, Sendai, Japan; Department of Neurology, Nishitaga National Hospital, Sendai, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan; Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa, Japan; Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, Ohio
George Perry: Department of Neurology, Tohoku University School of Medicine, Sendai, Japan; Department of Neurology, Nishitaga National Hospital, Sendai, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan; Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa, Japan; Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, Ohio
Mark A. Smith: Department of Neurology, Tohoku University School of Medicine, Sendai, Japan; Department of Neurology, Nishitaga National Hospital, Sendai, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan; Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa, Japan; Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, Ohio
Yasuto Itoyama: Department of Neurology, Tohoku University School of Medicine, Sendai, Japan; Department of Neurology, Nishitaga National Hospital, Sendai, Japan; Department of Neurology, Miyagi National Hospital, Miyagi, Japan; Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa, Japan; Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, Ohio

Journal volume & issue: Vol. 9, no. 2
pp. 244 – 248

Abstract

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8-hydroxy-2′-deoxyguanosine (8-OHdG) or 8-hydroxyguanosine (8-OHG), a product of oxidized DNA or RNA, is a good marker of oxidative cellular damage. In this study, we measured the 8-OHdG/8-OHG levels in the serum and cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) and multiple system atrophy (MSA). Compared to age-matched controls, the mean levels of serum 8-OHdG/8-OHG were significantly higher in PD (P < 0.0001). Although no gender differences were observed in the controls, the mean values of serum 8-OHdG/8-OHG were significantly higher in female PD cases (P < 0.005) than in male patients. 8-OHdG/8-OHG levels in CSF were also increased significantly in patients with PD and MSA, however, their relative values were generally much lower than those in the serum. Together with previous studies showing increased peripheral 8-OHdG levels in Alzheimer's disease and amyotrophic lateral sclerosis, the data presented here suggest that systemic DNA/RNA oxidation is commonly observed in neurodegenerative diseases. Our results also imply that female patients with PD show higher levels of oxidative stress, which may explain the faster progression of this disease in females.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

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