Infection and Drug Resistance (Aug 2022)
A Five-Year Retrospective Study of 746 Cases with Maxillofacial Space Infection in Western China
Abstract
Peihan Wang,1– 3,* Yanling Huang,1– 3,* Jie Long1– 3 1The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, 610041, People’s Republic of China; 2Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, 610041, People’s Republic of China; 3National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, 610041, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jie Long, Tel +86 28 85503406, Fax +86 28 85501456, Email [email protected]: To grasp the current epidemiological situation of maxillofacial space infection and investigate the risk factors contributing to the longer hospitalization of odontogenic space infection in western China.Patients and Methods: This retrospective study collected the clinical characteristics from 746 hospitalized patients with maxillofacial space infection and investigated the risk factors associated with longer hospitalization. Pearson’s chi-square test and multivariable binary logistic regression were performed for statistical analysis.Results: A total of 438 males and 308 females were included in this study, aging from 1 to 90 years (mean age 48.6 years). 74.9% cases resulted from odontogenic infections, with the submandibular space being the most commonly involved space (53.7%). Advanced age (OR (> 60 y:19– 60 y:≤ 18 y) = 3.784:3.416:1, p < 0.05), treatment before admission (OR = 2.271, p < 0.05) and number of involved spaces (OR (≥ 4:2– 3:1) = 3.204:1.931:1, p < 0.05) were closely related to longer hospitalization. Streptococcus being the most frequently found aerobic bacteria (268/615, 43.6%) of all the bacteria isolated was resistant to clarithromycin (91.5%) and erythromycin (92.8%).Conclusion: Hospitalization time could be longer for patients with the identified risk factors. Streptococcus, as the most common type of aerobic flora, is highly resistant to clindamycin and erythromycin.Keywords: maxillofacial space infection, epidemiological, odontogenic infections, hospitalization time, risk factors
