The Incidence, Outcomes, and Risk Factors of Secondary Poor Graft Function in Haploidentical Hematopoietic Stem Cell Transplantation for Acquired Aplastic Anemia

Fan Lin; Tingting Han; Yuanyuan Zhang; Yifei Cheng; Zhengli Xu; Xiaodong Mo; Fengrong Wang; Chenhua Yan; Yuqian Sun; Jingzhi Wang; Feifei Tang; Wei Han; Yuhong Chen; Yu Wang; Xiaohui Zhang; Kaiyan Liu; Xiaojun Huang; Xiaojun Huang; Lanping Xu

doi:10.3389/fimmu.2022.896034

Frontiers in Immunology (May 2022)

The Incidence, Outcomes, and Risk Factors of Secondary Poor Graft Function in Haploidentical Hematopoietic Stem Cell Transplantation for Acquired Aplastic Anemia

Fan Lin,
Tingting Han,
Yuanyuan Zhang,
Yifei Cheng,
Zhengli Xu,
Xiaodong Mo,
Fengrong Wang,
Chenhua Yan,
Yuqian Sun,
Jingzhi Wang,
Feifei Tang,
Wei Han,
Yuhong Chen,
Yu Wang,
Xiaohui Zhang,
Kaiyan Liu,
Xiaojun Huang,
Xiaojun Huang,
Lanping Xu

Affiliations

Fan Lin: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Collaborative Innovation Center of Hematology, Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China
Tingting Han: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Collaborative Innovation Center of Hematology, Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China
Yuanyuan Zhang: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Collaborative Innovation Center of Hematology, Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China
Yifei Cheng: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Collaborative Innovation Center of Hematology, Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China
Zhengli Xu: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Collaborative Innovation Center of Hematology, Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China
Xiaodong Mo: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Collaborative Innovation Center of Hematology, Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China
Fengrong Wang: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Collaborative Innovation Center of Hematology, Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China
Chenhua Yan: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Collaborative Innovation Center of Hematology, Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China
Yuqian Sun: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Collaborative Innovation Center of Hematology, Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China
Jingzhi Wang: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Collaborative Innovation Center of Hematology, Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China
Feifei Tang: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Collaborative Innovation Center of Hematology, Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China
Wei Han: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Collaborative Innovation Center of Hematology, Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China
Yuhong Chen: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Collaborative Innovation Center of Hematology, Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China
Yu Wang: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Collaborative Innovation Center of Hematology, Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China
Xiaohui Zhang: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Collaborative Innovation Center of Hematology, Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China
Kaiyan Liu: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Collaborative Innovation Center of Hematology, Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China
Xiaojun Huang: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Collaborative Innovation Center of Hematology, Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China
Xiaojun Huang: Peking-Tsinghua Centre for Life Sciences, Beijing, China
Lanping Xu: Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Collaborative Innovation Center of Hematology, Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China

DOI: https://doi.org/10.3389/fimmu.2022.896034
Journal volume & issue: Vol. 13

Abstract

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Secondary poor graft function (sPGF) increases the risk of life-threatening complications after hematopoietic stem cell transplantation (HSCT). The incidence, clinical outcomes, and risk factors of sPGF have not been elucidated in haploidentical (haplo-) HSCT for acquired aplastic anemia (AA) patients. We retrospectively reviewed 423 consecutive AA patients who underwent haplo-HSCT between January 2006 and December 2020 and report a 3-year cumulative incidence of 4.62% (95% confidence interval [CI]: 3.92%-10.23%) of sPGF. While no primary PGF occurred. The median time to sPGF was 121 days (range 30-626 days) after transplantation. To clarify the risk factors for sPGF, 17 sPGF cases and 382 without PGF were further analyzed. Compared to patients without PGF, the 2-year overall survival was significantly poorer for sPGF patients (67.7% vs 90.8%, p =.002). Twelve sPGF patients were alive until the last follow-up, and 7 achieved transfusion independency. The multivariable analyses revealed that later neutrophil engraftment (OR 2.819, p=.049) and a history of refractory cytomegalovirus viremia (OR=7.038, p=.002) post-transplantation were associated with sPGF. There was weak evidence that a history of grade 3-4 acute graft-versus-host disease increased the risk of sPGF (p=.063). We advocated better post-transplantation strategies to balance the risk of immunosuppression and viral reactivation for haplo-HSCT in AA patients.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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