The relationship between renal function and diabetic retinopathy in patients with type 2 diabetes: A three-year prospective study
Dongning Wang,
Kaiwei Fan,
Zhanpeng He,
Xiao Guo,
Xia Gong,
Kun Xiong,
Daheng Wei,
Bingbing Chen,
Fanxiao Kong,
Mochong Liao,
Wei Wang,
Wenyong Huang,
Hua Liu
Affiliations
Dongning Wang
Jinzhou Medical University, Jinzhou, Liaoning, China; Department of Ophthalmology, Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China
Kaiwei Fan
Neuromedical Center, The First People's Hospital of Zhaoqing, Zhaoqing City, People's Republic of China
Zhanpeng He
Liwan Central Hospital of Guangzhou, Guangzhou, People's Republic of China
Xiao Guo
Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, People's Republic of China
Xia Gong
Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, People's Republic of China
Kun Xiong
Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, People's Republic of China
Daheng Wei
Jinzhou Medical University, Jinzhou, Liaoning, China; Department of Ophthalmology, Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China
Bingbing Chen
Jinzhou Medical University, Jinzhou, Liaoning, China
Fanxiao Kong
Jinzhou Medical University, Jinzhou, Liaoning, China; Department of Ophthalmology, Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China
Mochong Liao
Jinzhou Medical University, Jinzhou, Liaoning, China; Department of Ophthalmology, Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China
Wei Wang
Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, People's Republic of China
Wenyong Huang
Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, People's Republic of China; Corresponding author. Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, 54S.Xianlie Road, Guangzhou, 510060, China.
Hua Liu
Jinzhou Medical University, Jinzhou, Liaoning, China; Department of Ophthalmology, Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China; Corresponding author.Jinzhou Medical University, the 40S. Songpo Road, Jinzhou, 121001, China.
Objective: To explore the association of diabetic retinopathy (DR) and diabetic macular edema (DME) with renal function in patients with type 2 diabetes mellitus (T2DM). Design: A prospective cohort study. Methods: This single-centre study included patients with no DR, mild non-proliferative DR (NPDR), and no DME at baseline. DR and DME were assessed using 7-field fundus photography and swept-source OCT (SS-OCT). The baseline renal function assessed included the estimated glomerular filtration rate (eGFR) and microalbuminuria (MAU). Cox regression analyses were used to assess the hazard ratio (HR) of renal function with the progression of DR and the development of DME. Results: A total of 1409 patients with T2DM (1409 eyes) were included. During 3 years of follow-up,143 patients had DR progression, and 54 patients developed DME. Low eGFR levels at baseline were associated with the development of DR (HR, 1.044 per 1-SD decrease; 95% CI, 1.035–1.053; P 90 mL/min/1.73 m2, the participants with eGFRs of 60–90 mL/min/1.73 m2 (HR, 1.649; 95% CI, 1.094–2.485; P = 0.017) or 0.05). Conclusions: Abnormal renal profiles (i.e., low levels of eGFR and high levels of MAU) were associated with the progression of DR, but not with the development of DME.
