The influence of genetic variability of DNA repair mechanisms on the risk of malignant mesothelioma

Levpuscek Kristina; Goricar Katja; Kovac Viljem; Dolzan Vita; Franko Alenka

doi:10.2478/raon-2019-0016

Radiology and Oncology (Mar 2019)

The influence of genetic variability of DNA repair mechanisms on the risk of malignant mesothelioma

Levpuscek Kristina,
Goricar Katja,
Kovac Viljem,
Dolzan Vita,
Franko Alenka

Affiliations

Levpuscek Kristina: Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Goricar Katja: Pharmacogenetics Laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Kovac Viljem: Institute of Oncology Ljubljana, Ljubljana, Slovenia
Dolzan Vita: Pharmacogenetics Laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Franko Alenka: Clinical Institute of Occupational Medicine, University Medical Center Ljubljana, Ljubljana, Slovenia

DOI: https://doi.org/10.2478/raon-2019-0016
Journal volume & issue: Vol. 53, no. 2
pp. 206 – 212

Abstract

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Malignant mesothelioma (MM) is a rare aggressive tumour of mesothelium caused by asbestos exposure. It has been suggested that the genetic variability of proteins involved in DNA repair mechanisms affects the risk of MM. This study investigated the influence of functional polymorphisms in ERCC1 and XRCC1 genes, the interactions between these polymorphisms as well as the interactions between these polymorphisms and asbestos exposure on MM risk.

Published in Radiology and Oncology

ISSN: 1581-3207 (Online)
Publisher: Sciendo
Country of publisher: Slovenia
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://sciendo.com/journal/RAON

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Abstract

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