A green approach to the synthesis of novel phytosphingolipidyl β-cyclodextrin designed to interact with membranes

Abstract

This work reports the synthesis of a new family of mono-substituted amphiphilic cyclodextrins using a green methodology. Reactions using greener and safer catalysts with more environmentally friendly purification solvents were performed. Four unreported mono-substituted cyclodextrins bearing a phytosphingolipidyl chain and a fatty acid chain (C10, C12, C14 and C18) were successfully obtained with a promising yield.

Keywords

• fatty ester
• green chemistry
• lipase
• mono-substituted amphiphilic cyclodextrins
• peptide Coupling
• solvent-free medium
• transesterification