MeCP2 regulates gene expression through recognition of H3K27me3

Wooje Lee; Jeeho Kim; Jung-Mi Yun; Takbum Ohn; Qizhi Gong

doi:10.1038/s41467-020-16907-0

Nature Communications (Jun 2020)

MeCP2 regulates gene expression through recognition of H3K27me3

Wooje Lee,
Jeeho Kim,
Jung-Mi Yun,
Takbum Ohn,
Qizhi Gong

Affiliations

Wooje Lee: Department of Cellular & Molecular Medicine, College of Medicine, Chosun University
Jeeho Kim: Department of Cellular & Molecular Medicine, College of Medicine, Chosun University
Jung-Mi Yun: Department of Food and Nutrition, Chonnam National University
Takbum Ohn: Department of Cellular & Molecular Medicine, College of Medicine, Chosun University
Qizhi Gong: Department of Cell Biology and Human Anatomy, University of California at Davis, School of Medicine

DOI: https://doi.org/10.1038/s41467-020-16907-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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MeCP2 is a transcriptional repressor and associates with nucleosomes. Here the authors show interaction of MeCP2 and H3K27me3 by biochemical assay and chromatin immunoprecipitation sequencing analysis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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