New Scabimycins A-C Isolated from <i>Streptomyces acidiscabies</i> (Lu19992)

Abstract

Peptide natural products displaying a wide range of biological activities have become important drug candidates over the years. Microorganisms have been a powerful source of such bioactive peptides, and Streptomyces have yielded many novel natural products thus far. In an effort to uncover such new, meaningful compounds, the metabolome of Streptomyces acidiscabies was analyzed thoroughly. Three new compounds, scabimycins A–C (1–3), were discovered, and their chemical structures were elucidated by NMR spectroscopy. The relative and absolute configurations were determined using ROESY NMR experiments and advanced Marfey’s method.

Keywords

• <i>Streptomyces</i>
• peptide natural products
• α,β-dehydroamino acid
• advanced Marfey’s method