OncoTargets and Therapy (Nov 2019)

Biomarkers Reflecting The Destruction Of The Blood-Brain Barrier Are Valuable In Predicting The Risk Of Lymphomas With Central Nervous System Involvement

  • Yu W,
  • Si M,
  • Li L,
  • He P,
  • Fan Z,
  • Zhang Q,
  • Jiao X

Journal volume & issue
Vol. Volume 12
pp. 9505 – 9512

Abstract

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Wenjun Yu,1,* Mengya Si,2,* Li Li,3,* Ping He,4 Zhiqiang Fan,4 Qiaoxin Zhang,2 Xiaoyang Jiao4 1Department of Hematology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, People’s Republic of China; 2Clinical Laboratory, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, People’s Republic of China; 3Obstetrics Department, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, People’s Republic of China; 4Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoyang JiaoDepartment of Cell Biology and Genetics, Shantou University Medical College, 22 Xinling Road, Guangdong 515041, People’s Republic of ChinaEmail [email protected]: We aimed to identify the biomarkers in cerebrospinal fluid (CSF) that facilitate the diagnosis of lymphomas with central nervous system (CNS) involvement.Methods: Four cases of non-Hodgkin’s lymphoma (NHL) patients with/without CNS involvement were enrolled respectively, and non-CNS tumor patients (n=3) were selected to be the controls. Lab biomarkers, cytokines, and tight junction proteins (TJs) in CSF and serum were measured.Results: When comparing the CNS to non-CNS group, cytokine including MMP-9 (15.24 vs 0.36 ng/mL), CCL-2 (1922.04 vs 490.68 pg/mL), and sVCAM-1 (61.36 vs 9.00 pg/mL), TJs including OCLN (6.68 vs 2.59 pg/mL), and ZO-1 (710.04 vs 182.98 pg/mL) in CSF were significantly higher in lymphomas patients with CNS involvement than those without CNS involvement. However, serum biomarkers were not significantly elevated. Contrary to the major findings, all conventional biomarkers and MRI results showed no significant change.Conclusion: CSF biomarkers affecting BBB disruption are valuable in mirroring the risk of lymphoma CNS metastasis. Further study with a larger sample size is needed to verify these biomarkers in predicting lymphoma CNS involvement.Keywords: lymphoma, CNS metastasis, cytokines, tight junction protein

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