Nature Communications (Mar 2018)

CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair

  • M. Charpentier,
  • A. H. Y. Khedher,
  • S. Menoret,
  • A. Brion,
  • K. Lamribet,
  • E. Dardillac,
  • C. Boix,
  • L. Perrouault,
  • L. Tesson,
  • S. Geny,
  • A. De Cian,
  • J. M. Itier,
  • I. Anegon,
  • B. Lopez,
  • C. Giovannangeli,
  • J. P. Concordet

DOI
https://doi.org/10.1038/s41467-018-03475-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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The integration of exogenous DNA into the genome using CRISPR–Cas9 often presents a challenge to researchers. Here the authors fuse CtIP to Cas9 to stimulate recombination at target loci.