Nanophotonics (Sep 2020)
A fiber optic–nanophotonic approach to the detection of antibodies and viral particles of COVID-19
- Rajil Navid,
- Sokolov Alexei,
- Yi Zhenhuan,
- Adams Garry,
- Agarwal Girish,
- Belousov Vsevolod,
- Brick Robert,
- Chapin Kimberly,
- Cirillo Jeffrey,
- Deckert Volker,
- Delfan Sahar,
- Esmaeili Shahriar,
- Fernández-González Alma,
- Fry Edward,
- Han Zehua,
- Hemmer Philip,
- Kattawar George,
- Kim Moochan,
- Lee Ming-Che,
- Lu Chao-Yang,
- Mogford Jon,
- Neuman Benjamin,
- Pan Jian-Wei,
- Peng Tao,
- Poor Vincent,
- Scully Steven,
- Shih Yanhua,
- Suckewer Szymon,
- Svidzinsky Anatoly,
- Verhoef Aart,
- Wang Dawei,
- Wang Kai,
- Yang Lan,
- Zheltikov Aleksei,
- Zhu Shiyao,
- Zubairy Suhail,
- Scully Marlan
Affiliations
- Rajil Navid
- Texas A&M University, College Station, TX77843, USA
- Sokolov Alexei
- Texas A&M University, College Station, TX77843, USA
- Yi Zhenhuan
- Texas A&M University, College Station, TX77843, USA
- Adams Garry
- Texas A&M University, College Station, TX77843, USA
- Agarwal Girish
- Texas A&M University, College Station, TX77843, USA
- Belousov Vsevolod
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow117997, Russia
- Brick Robert
- Texas A&M University, College Station, TX77843, USA
- Chapin Kimberly
- Texas A&M University, College Station, TX77843, USA
- Cirillo Jeffrey
- Texas A&M University, College Station, TX77843, USA
- Deckert Volker
- Texas A&M University, College Station, TX77843, USA
- Delfan Sahar
- Texas A&M University, College Station, TX77843, USA
- Esmaeili Shahriar
- Texas A&M University, College Station, TX77843, USA
- Fernández-González Alma
- Texas A&M University, College Station, TX77843, USA
- Fry Edward
- Texas A&M University, College Station, TX77843, USA
- Han Zehua
- Texas A&M University, College Station, TX77843, USA
- Hemmer Philip
- Texas A&M University, College Station, TX77843, USA
- Kattawar George
- Texas A&M University, College Station, TX77843, USA
- Kim Moochan
- Texas A&M University, College Station, TX77843, USA
- Lee Ming-Che
- Texas A&M University, College Station, TX77843, USA
- Lu Chao-Yang
- University of Science and Technology of China, Hefei, Anhui, 230026, P. R. China
- Mogford Jon
- Texas A&M University System, College Station, TX77840, USA
- Neuman Benjamin
- Texas A&M University, College Station, TX77843, USA
- Pan Jian-Wei
- University of Science and Technology of China, Hefei, Anhui, 230026, P. R. China
- Peng Tao
- Texas A&M University, College Station, TX77843, USA
- Poor Vincent
- Princeton University, Princeton, NJ08544, USA
- Scully Steven
- Collins Aerospace, Richardson, TX75082, USA
- Shih Yanhua
- University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD21250, USA
- Suckewer Szymon
- Texas A&M University, College Station, TX77843, USA
- Svidzinsky Anatoly
- Texas A&M University, College Station, TX77843, USA
- Verhoef Aart
- Texas A&M University, College Station, TX77843, USA
- Wang Dawei
- Zhejiang University, 38 Zheda Rd, Hangzhou, 310027, P. R. China
- Wang Kai
- Texas A&M University, College Station, TX77843, USA
- Yang Lan
- Washington University, St. Louis, MO63130, USA
- Zheltikov Aleksei
- Texas A&M University, College Station, TX77843, USA
- Zhu Shiyao
- Zhejiang University, 38 Zheda Rd, Hangzhou, 310027, P. R. China
- Zubairy Suhail
- Texas A&M University, College Station, TX77843, USA
- Scully Marlan
- Texas A&M University, College Station, TX77843, USA
- DOI
- https://doi.org/10.1515/nanoph-2020-0357
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 235 – 246
Abstract
Dr. Deborah Birx, the White House Coronavirus Task Force coordinator, told NBC News on “Meet the Press” that “[T]he U.S. needs a ‘breakthrough’ in coronavirus testing to help screen Americans and get a more accurate picture of the virus’ spread.” We have been involved with biopathogen detection since the 2001 anthrax attacks and were the first to detect anthrax in real-time. A variation on the laser spectroscopic techniques we developed for the rapid detection of anthrax can be applied to detect the Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2 virus). In addition to detecting a single virus, this technique allows us to read its surface protein structure. In particular, we have been conducting research based on a variety of quantum optical approaches aimed at improving our ability to detect Corona Virus Disease-2019 (COVID-19) viral infection. Indeed, the detection of a small concentration of antibodies, after an infection has passed, is a challenging problem. Likewise, the early detection of disease, even before a detectible antibody population has been established, is very important. Our team is researching both aspects of this problem. The paper is written to stimulate the interest of both physical and biological scientists in this important problem. It is thus written as a combination of tutorial (review) and future work (preview). We join Prof. Federico Capasso and Editor Dennis Couwenberg in expressing our appreciation to all those working so heroically on all aspects of the COVID-19 problem. And we thank Drs. Capasso and Couwenberg for their invitation to write this paper.
Keywords
