Novel approaches to tuberculosis vaccine development

Abstract

Tuberculosis (TB) remains the deadliest infectious disease. The widely used bacille Calmette–Guérin (BCG) vaccine offers only limited protection against TB. New vaccine candidates for TB include subunit vaccines and inactivated whole-cell vaccines, as well as live mycobacterial vaccines. Current developments in TB vaccines are summarized in this review.

Keywords

• Preventive vaccine
• Therapeutic vaccine
• Pre-exposure vaccine
• Post-exposure vaccine
• Subunit vaccine
• Whole-cell vaccine