PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development

Mei Yu; Yuhong Chen; Hu Zeng; Yongwei Zheng; Guoping Fu; Wen Zhu; Ulrich Broeckel; Praful Aggarwal; Amy Turner; Geoffrey Neale; Cliff Guy; Nan Zhu; Hongbo Chi; Renren Wen; Demin Wang

doi:10.1038/s41467-017-01388-5

Nature Communications (Nov 2017)

PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development

Mei Yu,
Yuhong Chen,
Hu Zeng,
Yongwei Zheng,
Guoping Fu,
Wen Zhu,
Ulrich Broeckel,
Praful Aggarwal,
Amy Turner,
Geoffrey Neale,
Cliff Guy,
Nan Zhu,
Hongbo Chi,
Renren Wen,
Demin Wang

Affiliations

Mei Yu: Blood Research Institute, Blood Center of Wisconsin
Yuhong Chen: Blood Research Institute, Blood Center of Wisconsin
Hu Zeng: Department of Immunology, St. Jude Children’s Research Hospital
Yongwei Zheng: Blood Research Institute, Blood Center of Wisconsin
Guoping Fu: Blood Research Institute, Blood Center of Wisconsin
Wen Zhu: Blood Research Institute, Blood Center of Wisconsin
Ulrich Broeckel: Section of Genomic Pediatrics, Department of Pediatrics, Medical College of Wisconsin
Praful Aggarwal: Section of Genomic Pediatrics, Department of Pediatrics, Medical College of Wisconsin
Amy Turner: Section of Genomic Pediatrics, Department of Pediatrics, Medical College of Wisconsin
Geoffrey Neale: Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children’s Research Hospital
Cliff Guy: Department of Immunology, St. Jude Children’s Research Hospital
Nan Zhu: Blood Research Institute, Blood Center of Wisconsin
Hongbo Chi: Department of Immunology, St. Jude Children’s Research Hospital
Renren Wen: Blood Research Institute, Blood Center of Wisconsin
Demin Wang: Blood Research Institute, Blood Center of Wisconsin

DOI: https://doi.org/10.1038/s41467-017-01388-5
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 18

Abstract

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IL-7R activation drives early B cell development, but the signalling is unclear. Here the authors show PLCγ is involved in IL-7R-induced mTOR activation via a DAG/PKC-dependent pathway, and that double deficiency of the two PLCγ isoforms arrests B cell development at the pre-pro-B stage in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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