Personalized predictions and non-invasive imaging of human brain temperature

Abstract

While progress has been made to formulate models for brain temperature regulation that incorporate non-simplified anatomy and vasculature, accounting for heterogeneity between individuals is still a challenge. Here, the authors propose a fully conserved biophysical model that, starting from an individual subject’s magnetic resonance-derived tissue and vessel structure, predicts individual patterns in local brain temperature in agreement with magnetic resonance thermometry.