The Effect of Eight-week Concurrent Training On The Plasma And Gene Expression Levels VEGFR-1 and VEGFR-2 in Men with Prostate Cancer

Abstract

Introduction physical activity has been considered as an effective intervention of prostate cancer treatment strategies by modulating angiogenesis in the tumor. The aim of this study was to investigate the effect of eight-week concurrent training on the plasma and gene expression levels of VEGFR-1 and VEGFR-2 of men with prostate cancer. Materials and Methods In this clinical trial study, 20 men with prostate cancer (age = 62/2 ± 5/69 years old, stage 1 & stage 2) were randomly selected of Baqiyatallah al-Achr('39')zam sub-hospital in Tehran and Patients were divided into two groups of experimental and control. The experimental group performed 8 weeks training including 3 sessions/week. The workouts were the combination of exercises with resistance and endurance training per session as 60-75%, one-repetition maximum, and 60-75% of maximum heart rate. The Blood samples were tested for VEGFR-1 and VEGFR-2 using ELISA and Real-Time PCR methods, respectively, and the data were analyzed using dependent and independent t-test at the significant level p≤0/05. Results The results showed that the effect of eight-week concurrent training significantly decreased in BMI (p=0/001) and a significant increase in Vo2peak (p≤0/005) and strength (p≤0/001) the experimental group. Also, significantly decreased plasma levels (p≤0/007) and expression of VEGFR-1 and VEGFR-2 gene (p≤0/03 & p≤0/04) the experimental group compared with control group (P <0.05). Conclusion Considering the importance of VEGFR-1 and VEGFR-2 as the main intermediaries of cell signal transduction for angiogenesis and tumor extension, probably the effect of eight-week concurrent training by modifing angiogenesis of tumor microenvironment can be effective in reducing the progression of prostate cancer.

Keywords

• angiogenesis
• exercise training
• prostate cancer
• vegfr-1
• vegfr-2