Di-san junyi daxue xuebao (Apr 2022)

Effects of uric acid level on prognosis of heart failure vulnerable stage in patients with acute heart failure

  • HE Xiaolong,
  • LUO Xiaoyu,
  • GUO Zhinian,
  • HU Huajuan,
  • CHEN Yunlong

DOI
https://doi.org/10.16016/j.2097-0927.202201017
Journal volume & issue
Vol. 44, no. 8
pp. 812 – 817

Abstract

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Objective To investigate the relationship between different serum uric acid (SUA) levels after admission and the incidence of cardiac major adverse cardiac events (MACE) in the vulnerable stage of heart failure after discharge in patients with acute heart failure (AHF). Methods Clinical data of AHF patients admitted to our department from October 2019 to July 2021 were collected, and all of them were followed up for 3 months. According to whether MACE events occurred during the vulnerable period after discharge, the patients were divided into event group and control group. The differences of the baseline data were compared between the 2 groups, and the factors that may affect the MACE events in the vulnerable period were analyzed with multivariate logistic regression analysis. The correlation between high SUA level and prognosis in the vulnerable period was analyzed. Results A total of 539 hospitalized AHF patients were included in this study, including 194 (35.9%) in the event group and 345 (64.1%) in the control group. In the event group, 175 cases (90.3%) had high SUA level and 19 cases (9.7%) had normal SUA level (P < 0.05). The event group had higher levels of SUA, D-dimer, blood urea nitrogen, brain natriuretic peptide (BNP) and NYHA cardiac function class, left atrial anteroposterior diameter, and left ventricular transverse diameter (P < 0.05), while lower body mass index (BMI), mean arterial pressure, serum sodium, albumin, and total cholesterol (TC) (P < 0.05). Logistic regression analysis showed that high SUA (OR=3.419, 95%CI: 1.805~6.477, P < 0.05) was an independent risk factor for MACE events in the vulnerable period of AHF patients. Conclusion The AHF patients with high SUA level are prone to the occurrence of MACE events in the vulnerable period after discharge. SUA is a helpful indicator for evaluating the prognosis of AHF patients in the vulnerable period.

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