Empowering alcohols as carbonyl surrogates for Grignard-type reactions

Chen-Chen Li; Haining Wang; Malcolm M. Sim; Zihang Qiu; Zhang-Pei Chen; Rustam Z. Khaliullin; Chao-Jun Li

doi:10.1038/s41467-020-19857-9

Nature Communications (Nov 2020)

Empowering alcohols as carbonyl surrogates for Grignard-type reactions

Chen-Chen Li,
Haining Wang,
Malcolm M. Sim,
Zihang Qiu,
Zhang-Pei Chen,
Rustam Z. Khaliullin,
Chao-Jun Li

Affiliations

Chen-Chen Li: Department of Chemistry and FQRNT Centre for Green Chemistry and Catalysis, McGill University
Haining Wang: Department of Chemistry and FQRNT Centre for Green Chemistry and Catalysis, McGill University
Malcolm M. Sim: Department of Chemistry and FQRNT Centre for Green Chemistry and Catalysis, McGill University
Zihang Qiu: Department of Chemistry and FQRNT Centre for Green Chemistry and Catalysis, McGill University
Zhang-Pei Chen: Department of Chemistry and FQRNT Centre for Green Chemistry and Catalysis, McGill University
Rustam Z. Khaliullin: Department of Chemistry and FQRNT Centre for Green Chemistry and Catalysis, McGill University
Chao-Jun Li: Department of Chemistry and FQRNT Centre for Green Chemistry and Catalysis, McGill University

DOI: https://doi.org/10.1038/s41467-020-19857-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 9

Abstract

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Alcohols are more naturally abundant than carbonyl compounds, which in turn are well known for their reactivity in Grignard reactions. Here, the authors showcase a distinct Grignard-like reactivity by using alcohols as coupling partners with hydrazones and synthesize more complex alcohols under ruthenium catalysis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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