DNA origami presenting the receptor binding domain of SARS-CoV-2 elicit robust protective immune response

Esra Oktay; Farhang Alem; Keziah Hernandez; Michael Girgis; Christopher Green; Divita Mathur; Igor L. Medintz; Aarthi Narayanan; Remi Veneziano

doi:10.1038/s42003-023-04689-2

Communications Biology (Mar 2023)

DNA origami presenting the receptor binding domain of SARS-CoV-2 elicit robust protective immune response

Esra Oktay,
Farhang Alem,
Keziah Hernandez,
Michael Girgis,
Christopher Green,
Divita Mathur,
Igor L. Medintz,
Aarthi Narayanan,
Remi Veneziano

Affiliations

Esra Oktay: Department of Bioengineering, George Mason University
Farhang Alem: National Center for Biodefense and Infectious Diseases, George Mason University
Keziah Hernandez: National Center for Biodefense and Infectious Diseases, George Mason University
Michael Girgis: Department of Bioengineering, George Mason University
Christopher Green: Center for Bio/Molecular Science and Engineering Code 6900, U.S. Naval Research Laboratory
Divita Mathur: Department of Chemistry, Case Western Reserve University
Igor L. Medintz: Center for Bio/Molecular Science and Engineering Code 6900, U.S. Naval Research Laboratory
Aarthi Narayanan: National Center for Biodefense and Infectious Diseases, George Mason University
Remi Veneziano: Department of Bioengineering, George Mason University

DOI: https://doi.org/10.1038/s42003-023-04689-2
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 11

Abstract

Read online

A DNA origami nanoparticle-based vaccine against SARS-Cov-2 co-delivers viral RBD antigen and CpG adjuvant and elicits a robust protective immunity against the virus in a mouse model.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal